Abstracts

Ocular Pseudoexfoliation Syndrome and Its Association with Cardiovascular Disease and Homocystinuria: A Meta-Analysis

Authors: Juan Siordia (University of Arizona) , Catherine R. Coverley (University of Arizona)

Abstract

Pseudoexfoliation syndrome (PEX) is a common cause of open angle glaucoma and is associated with multiple ocular pathologies including the acceleration of cataracts. PEX is characterized by stress-induced elastic microfibrillopathy related to an accumulation of matrix metalloproteinases. The accumulation of matrix metalloproteinases increases deposition of protein substance within ocular structures and other organs including the heart. Many studies have associated the presence of cardiovascular disease with pseudoexfoliation syndrome, but none have specified which particular disorders occur. The following meta-analysis aims to relate PEX with certain cardiovascular events and disorders.

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How to Cite: Siordia, J. & Coverley, C. R. (2016) “Ocular Pseudoexfoliation Syndrome and Its Association with Cardiovascular Disease and Homocystinuria: A Meta-Analysis”, University of Arizona Journal of Medicine. 1(1).