Articles

MICROSPHERES IN CARDIAC LYMPH: CONTROL AND ISCHEMIC STATES

Authors: LH Michael ( ) , JR Hunt ( ) , RM Lewis ( ) , ML Entman ( )

Abstract

The cardiac lymph from conscious animals was moni­tored for the presence or absence of radiolabelled 15 micrometer microspheres during: a) control periods after left atrial injection of microspheres and b) after circumflex coronary artery (CFX) occlusions (10-20 min total or < 40 mins 50% of control flow) followed by full reperfusions. Microspheres (15µ) numbering 7-150 were present in the lymph within 2 hrs after the occlusions; and in three experiments, the presence of a small number in the lymph on the following day implied continual release overnight. No microspheres were present in 8-48 hr lymph samples prior to occlusions. This study suggests that some microspheres escape from the intravascular spaze of the myocardium and are channeled into the cardiac lymphatics; this is apparent even after short-term ischemic events.

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How to Cite: Michael, L. , Hunt, J. , Lewis, R. & Entman, M. (1981) “MICROSPHERES IN CARDIAC LYMPH: CONTROL AND ISCHEMIC STATES”, Lymphology. 14(3).