ISOPROSTANE 8-EPI-PROSTAGLANDIN F2α IS A POTENT CONTRACTOR OF HUMAN PERIPHERAL LYMPHATICS

H Sinzinger; A Oguogho; J Kaliman

Articles

ISOPROSTANE 8-EPI-PROSTAGLANDIN F_2α IS A POTENT CONTRACTOR OF HUMAN PERIPHERAL LYMPHATICS

Authors: H Sinzinger ( ) , A Oguogho ( ) , J Kaliman ( )

Abstract

Isoprostanes are products of free radical-catalyzed peroxidation and 8-epiprostaglandin (PG) F_2α is the most important vasomodulator of this group of compounds. In human lower leg lymphatics isolated from 5 different patients without a smoking history or hyperlipidemia, 8-epi-PGF_2α stimulated in vitro contraction more strongly than the thromboxane receptor agonist U46619. Other isoprostanes (8-epi-PGE₁, 8-epi-PGE₂) had only limited lymphatic contractile potency. These data suggest a potentially relevant role for 8-epi-PGF_2α in facilitating lymph transport especially in conditions of inflammation.

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How to Cite: Sinzinger, H. , Oguogho, A. & Kaliman, J. (1997) “ISOPROSTANE 8-EPI-PROSTAGLANDIN F_2α IS A POTENT CONTRACTOR OF HUMAN PERIPHERAL LYMPHATICS”, Lymphology. 30(3).