Epstein-Barr virus-associated transformation of primary cutaneous follicle center lymphoma to diffuse large B-cell lymphoma, a case and review of the literature

Abstract

Primary cutaneous follicle center lymphoma (PCFCL) is a rare, indolent neoplasm with a good prognosis. Transformations of PCFCL into more aggressive non-Hodgkin lymphomas, such as diffuse large B-cell lymphoma (DLBCL), are extremely uncommon, with few cases reported in the literature. We present a case report of an 84-year-old man with a history of PCFCL who presented 26 months after initial treatment with an enlarged lymph node in the right neck. Excisional biopsy revealed DLBCL. Further studies showed the presence of Epstein-Barr virus (EBV), and molecular studies were consistent with the two neoplasms being clonally related. Taken together, these findings suggest an EBV-driven transformation of PCFCL to DLBCL in this patient.

Keywords

Primary cutaneous follicle center lymphoma (PCFCL), Epstein-Barr virus (EBV), diffuse large B-cell lymphoma (DLBCL), transformation

How to Cite

Alver, A. & Haycocks, N. G., (2021) “Epstein-Barr virus-associated transformation of primary cutaneous follicle center lymphoma to diffuse large B-cell lymphoma, a case and review of the literature”, Hematopathology 5(1), 12-17.

Download

Download PDF

139

Views

96

Downloads

Share

Authors

Amalie Alver (University of Nevada, Las Vegas School of Medicine)
Neil G. Haycocks (Frank H. Netter MD School of Medicine at Quinnipiac University, Hamden, CT)

Download

Issue

Publication details

Dates

Licence

Creative Commons Attribution-NonCommercial 4.0

Peer Review

This article has been peer reviewed.

File Checksums (MD5)

  • PDF: 38f70f3c44d99552befde975818f9d4b